Bioactive Small Molecules
Medchemexpress LLC BMS-199264 hydrochloride | 186180-83-6 | MFCD00087197 | 99.3% | 567.53 g·mol⁻¹ | C26H32Cl2N4O4S | 5 MG
BMS-199264 hydrochloride is the hydrochloride salt of a small-molecule inhibitor of mitochondrial F1F0 ATP hydrolase. It selectively inhibits ATP hydrolysis (reported IC50 = 0.5 μM), reduces ATP decline during ischemia, and has been reported to improve recovery of contractile function after reperfusion.
- Inhibits mitochondrial F1F0 ATP hydrolase (IC50 ≈ 0.5 μM).
- Reduces ATP decline during ischemic conditions.
- Enhances recovery of contractile function after reperfusion.
- Provided as a hydrochloride salt for improved stability.
- High purity suitable for research applications (~99.3%).
- Available in small research quantities, e.g., 5 MG.
![Medchemexpress LLC 2,3-dimethoxy-13-(2-(pyrrolidin-1-yl)ethoxy)-dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine | 2248702-80-7 | 98.3% | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000233901.png-250.jpg)
Medchemexpress LLC 2,3-dimethoxy-13-(2-(pyrrolidin-1-yl)ethoxy)-dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine | 2248702-80-7 | 98.3% | 5 MG
TDP1 Inhibitor-1 is a small-molecule research compound that inhibits Tyrosyl-DNA phosphodiesterase 1 (TDP1) and is used to probe DNA repair and cytotoxicity in cell-based cancer research.
- Inhibits TDP1; reported IC50 ≈ 7 μM.
- Molecular weight 446.5 g/mol; formula C26H26N2O5.
- Purity 98.3% (reported by supplier).
- Supplied in small milligram pack sizes suitable for laboratory studies.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC XTT (sodium) | 111072-31-2 | 99.9% | 100 MG
XTT (sodium) is a tetrazolium-based reagent used to assess cell viability and cytotoxicity. Metabolically active cells reduce the water-soluble XTT sodium salt to an orange formazan, and the formazan absorbance is measured colorimetrically to quantify cell metabolic activity.
- Produces a water-soluble orange formazan for direct colorimetric readout.
- Measures metabolic activity of viable cells via tetrazolium reduction.
- Suitable for mammalian cell viability and cytotoxicity assays.
- Compatible with microplate and high-throughput formats.
- Supplied as a sodium salt powder for preparation of aqueous working solutions.
![Medchemexpress LLC 3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol | 1431985-92-0 | 99.7% | 10MM 1ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230662.png-250.jpg)
Medchemexpress LLC 3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol | 1431985-92-0 | 99.7% | 10MM 1ML
3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol | 1431985-92-0 | 99.7% | 10MM 1ML
Medchemexpress LLC LDN-193189 monohydrochloride | 1062368-62-0 | >=98.0% | 25 MG
LDN193189 hydrochloride is the hydrochloride salt of LDN193189, a selective small-molecule inhibitor of BMP type I receptors used as a biochemical reagent for in vitro research and biochemical assays.
- Hydrochloride salt form for improved solubility.
- Molecular formula C25H23ClN6.
- Molecular weight 442.94 g/mol.
- CAS number 1062368-62-0.
- Typical purity ≥98.0% (HPLC).
- Storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or diagnostic applications.
Medchemexpress LLC DBCO-NHS ester 2 5mg | 1384870-47-6 | 430.45 g/mol | C25H22N2O5 | 5 MG
DBCO-NHS ester 2 is an amine-reactive DBCO-derived N-hydroxysuccinimide (NHS) ester used as a click-chemistry linker for strain-promoted alkyne-azide cycloaddition (SPAAC). It enables copper-free conjugation to azide-containing partners and is commonly used in bioconjugation and linker synthesis workflows.
- Enables copper-free SPAAC with azide-containing partners.
- Reacts with primary amines via NHS ester chemistry to form stable amide bonds.
- Useful for linker and probe synthesis in antibody-drug conjugate and labeling applications.
- Provided in small research-scale masses for convenient handling and formulation.
![Medchemexpress LLC 4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | 1206711-16-1 | >98.0% | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000231466.png-250.jpg)
Medchemexpress LLC 4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | 1206711-16-1 | >98.0% | 5 MG
DMH-1 is a small-molecule inhibitor of bone morphogenetic protein (BMP) type I receptors used in research to probe BMP/TGF-β signaling pathways. It provides potent, selective inhibition of ALK family kinases and is supplied as a high-purity analytical standard.
- Selective BMP type I receptor inhibitor with low-nanomolar activity.
- Reported IC50s: ALK1 27 nM; ALK2 107.9 nM; ALK3 <5 nM; ALK6 47.6 nM.
- Molecular formula C24H20N4O and molecular weight 380.44 g/mol.
- Purity ≥98% (HPLC).
- CAS number 1206711-16-1 for substance identification.
Medchemexpress LLC 1,6-Anhydro-β-D-mannopyranose | 14168-65-1 | MFCD00069698 | 99.2% | 162.14 | C6H10O5 | 250MG
Mannosan (1,6-anhydro-β-D-mannopyranose) is an anhydro sugar reagent supplied as a white to off-white solid for use in glycobiology and carbohydrate research. It is provided in multiple laboratory pack sizes for analytical and preparative work, and has formula C6H10O5 and molecular weight 162.14.
- Purity determined at 99.18%.
- Molecular formula C6H10O5 and molecular weight 162.14.
- Available in small laboratory pack sizes suitable for research use.
- White to off-white solid, easy to handle and store.
- Used as a reagent in glycobiology and carbohydrate chemistry applications.
Medchemexpress LLC Disopyramide phosphate | 22059-60-5 | MFCD00069254 | 99.9% | 437.47 | C21H32N3O5P | 100MG
Disopyramide phosphate is the phosphate salt of disopyramide, a class IA antiarrhythmic used in research to study cardiac electrophysiology. It blocks the fast inward sodium current, prolongs cardiac action potentials, inhibits hERG-encoded potassium channels, and exhibits negative inotropic effects. Supplied as a high-purity reference standard, it is intended for in vitro pharmacology and electrophysiology applications.
- High purity suitable for analytical and reference use.
- Available in multiple pack sizes including 100 mg for experimental flexibility.
- Chemical formula C21H32N3O5P and molecular weight 437.47 g/mol for accurate dosing and calculations.
- Relevant for sodium channel and cardiac action potential research.
- Solid form enables straightforward storage and handling.
Medchemexpress LLC AMP-PCP disodium 5mg | 7414-56-4 | 5MG
AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3 8 M AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90[1
Medchemexpress LLC Driselase from Basidiomycetes sp. | 85186-71-6 | MFCD00130978 | >10.0% | 100MG
Driselase from Basidiomycetes sp. is a commercial enzyme preparation composed of multiple fungal carbohydrolase activities used to digest plant cell walls and facilitate protoplast formation. Supplied as a white to yellow solid powder, it is soluble in water and formulated for enzymatic hydrolysis of cellulose, hemicellulose, and pectin components in research applications.
Medchemexpress LLC Ceftobiprole medocaril sodium | 252188-71-9 | 95.7% | 712.64 g/mol | C26H25N8NaO11S2 | 10 MG
Ceftobiprole medocaril sodium is the parenteral prodrug (sodium salt) of ceftobiprole, a pyrrolidinone cephalosporin antibiotic supplied for research use. It displays broad-spectrum in vitro antibacterial activity and is provided as an off-white to light yellow solid for biochemical and antimicrobial studies.
- Parenteral prodrug sodium salt suitable for in vitro research.
- Broad-spectrum activity including MRSA and penicillin-resistant streptococci.
- Purity approximately 95.7% with solid appearance.
- Molecular weight 712.64 g/mol; formula C26H25N8NaO11S2.
- Recommended storage: 4°C sealed; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Thal-sns-032 | 2139287-33-3 | >98.0% | 869.02 g·mol⁻¹ | C40H52N8O10S2 | 1MG
THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of the CDK-binding ligand SNS-032 linked to a thalidomide-derived cereblon (CRBN) E3 ligase ligand. It promotes CRBN-dependent ubiquitination and proteasomal degradation of CDK9 and is supplied as a high-purity research compound for in vitro target degradation and mechanistic studies.
- Selective CDK9 degradation via cereblon recruitment.
- Reported potency with EC50 ≈ 4 nM in cell-based assays.
- High purity (≥98% by HPLC) suitable for research use.
- Molecular weight 869.02 g·mol⁻¹ and defined molecular formula.
- Designed for use in mechanistic and pharmacology studies of targeted protein degradation.
Medchemexpress LLC PKC-theta inhibitor 1 | 1160501-81-4 | 99.7% | 348.32 g·mol⁻¹ | C17H15F3N4O | 5MG
PKC-theta inhibitor 1 is an orally active, selective ATP-competitive inhibitor of protein kinase C theta (PKCθ) used in biochemical and cellular research to probe PKCθ-mediated signaling pathways. It is a small-molecule research reagent with reported high potency and listed high purity.
- Selective ATP-competitive inhibition of PKCθ for target-specific studies.
- High potency with reported Ki ≈ 6 nM.
- High purity (99.7%) suitable for biochemical assays.
- Characterized small molecule with formula C17H15F3N4O and molecular weight 348.32 g·mol⁻¹.
- Available in multiple research pack sizes for assay flexibility.
Medchemexpress LLC A 922500 | 959122-11-3 | 99.3% | 428.48 g·mol⁻¹ | C26H24N2O4 | 1 MG
A 922500 is a potent, selective, orally bioavailable diacylglycerol acyltransferase 1 (DGAT-1) inhibitor used as a research reagent for biochemical and in vivo studies of lipid metabolism and pharmacology. It exhibits low-nanomolar activity against human and mouse DGAT-1 and is provided with validated purity and characterization data.
- Potent, low-nanomolar DGAT-1 inhibition (IC50 ≈ 9 nM human, 22 nM mouse).
- High purity suitable for research applications.
- Available as powder and ready-to-use DMSO solution formats.
- Characterized with COA, LC-MS, HNMR, and RP-HPLC data.
- Soluble in DMSO and formulated for in vivo use per published protocols.
- Stable under recommended frozen and refrigerated storage conditions.